Cefonicid Sodium
The sodium salt formulation of cefonicid retains the long-acting second-generation cephalosporin activity suitable for once-daily parenteral administration. It is used for respiratory, urinary, skin, and bone infections in outpatient and inpatient settings. Standard cephalosporin precautions regarding allergy history and renal function apply.
Molecular Weight
586.5000 g/mol
TPSA
270.00 Ų
Mechanism of Action
Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.
2D Structure
Cite this structure
Embed this structure
SMILES
O=C([O-])C1=C(CSc2nnnn2CS(=O)(=O)[O-])CS[C@@H]2[C@H](NC(=O)[C@H](O)c3ccccc3)C(=O)N12.[Na+].[Na+]
InChI
InChI=1S/C18H18N6O8S3.2Na/c25-13(9-4-2-1-3-5-9)14(26)19-11-15(27)24-12(17(28)29)10(6-33-16(11)24)7-34-18-20-21-22-23(18)8-35(30,31)32;;/h1-5,11,13,16,25H,6-8H2,(H,19,26)(H,28,29)(H,30,31,32);;/q;2*+1/p-2/t11-,13-,16-;;/m1../s1
Molecular Formula
C18H16N6Na2O8S3
HBD / HBA
2 / 13
Rotatable Bonds
7
Heavy Atoms
37
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
The sodium salt formulation of cefonicid retains the long-acting second-generation cephalosporin activity suitable for once-daily parenteral administration. It is used for respiratory, urinary, skin, and bone infections in outpatient and inpatient settings. Standard cephalosporin precautions regarding allergy history and renal function apply.
Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.
Yes, Cefonicid Sodium is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201005. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 43593. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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