Codeine

CHEMBL485 Phase 4 Approved Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

299.4 g/mol

LogP

1.1

Phase

4

A naturally occurring opioid analgesic and cough suppressant that is converted in the body to morphine, providing pain relief and suppression of the cough reflex. It is used for mild to moderate pain and as a component of some cough syrups.

Molecular Weight

299.4000 g/mol

LogP

1.10

TPSA

41.90 Å²

Lipinski RO5

Pass

Therapeutic Areas

Asthma Bipolar Disorder Bladder Cancer Breast Cancer Cardiovascular Disease Chronic Kidney Disease Chronic Pain Colorectal Cancer Epilepsy Generalized Anxiety Disorder Heart Failure Hypertension Insomnia Leukemia Lymphoma Major Depressive Disorder Migraine Multiple Sclerosis Non-Small Cell Lung Cancer Obesity Ovarian Cancer Pain Management Pancreatic Cancer Parkinson's Disease Prostate Cancer Schizophrenia Thyroid Cancer

Mechanism of Action

Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mechanism

Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission …

2D Structure

SVG PNG

Cite this structure

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SMILES

COc1ccc2c3c1O[C@H]1[C@@H](O)C=C[C@H]4[C@@H](C2)N(C)CC[C@@]341

InChI

InChI=1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3-6,11-13,17,20H,7-9H2,1-2H3/t11-,12+,13-,17-,18-/m0/s1

Molecular Formula

C18H21NO3

HBD / HBA

1 / 4

Rotatable Bonds

1

Heavy Atoms

22

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Frequently Asked Questions

A naturally occurring opioid analgesic and cough suppressant that is converted in the body to morphine, providing pain relief and suppression of the cough reflex. It is used for mild to moderate pain and as a component of some cough syrups.

Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.

Yes, Codeine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL485. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 5284371. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Structure

Quick Data

Formula: C18H21NO3
Synonyms: 63

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Medical Disclaimer

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.