Copanlisib

CHEMBL3218576 Phase 4 Approved Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

480.5 g/mol

LogP

0.3

Phase

4

A pan-PI3K inhibitor given intravenously that blocks phosphoinositide 3-kinase signaling pathways involved in tumor cell growth and survival, approved for relapsed follicular lymphoma. It predominantly inhibits the PI3K-alpha and PI3K-delta isoforms.

Molecular Weight

480.5000 g/mol

LogP

0.30

TPSA

140.00 Å²

Lipinski RO5

Pass

Therapeutic Areas

Bladder Cancer Breast Cancer Colorectal Cancer Leukemia Lymphoma Melanoma Non-Small Cell Lung Cancer Oncology Ovarian Cancer Pancreatic Cancer Prostate Cancer Thyroid Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

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SMILES

COc1c(OCCCN2CCOCC2)ccc2c1N=C(NC(=O)c1cnc(N)nc1)N1CCN=C21

InChI

InChI=1S/C23H28N8O4/c1-33-19-17(35-10-2-6-30-8-11-34-12-9-30)4-3-16-18(19)28-23(31-7-5-25-20(16)31)29-21(32)15-13-26-22(24)27-14-15/h3-4,13-14H,2,5-12H2,1H3,(H2,24,26,27)(H,28,29,32)

Molecular Formula

C23H28N8O4

HBD / HBA

2 / 9

Rotatable Bonds

7

Heavy Atoms

35

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Frequently Asked Questions

A pan-PI3K inhibitor given intravenously that blocks phosphoinositide 3-kinase signaling pathways involved in tumor cell growth and survival, approved for relapsed follicular lymphoma. It predominantly inhibits the PI3K-alpha and PI3K-delta isoforms.

Yes, Copanlisib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3218576. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 135565596. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Structure

Quick Data

Formula: C23H28N8O4

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Medical Disclaimer

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.