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Daclatasvir Dihydrochloride

CHEMBL2303621 Phase 4 Approved Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
811.8 g/mol
LogP
—
Phase
4

The dihydrochloride salt form of daclatasvir, a hepatitis C NS5A inhibitor used in combination antiviral regimens. The salt formulation provides improved stability and bioavailability.

Molecular Weight

811.8000 g/mol

TPSA

175.00 Ų

Therapeutic Areas

Hepatitis C

Mechanism of Action

Inhibits the NS5A protein of hepatitis C virus, disrupting viral RNA replication and virion assembly.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mechanism

Inhibits the NS5A protein of hepatitis C virus, disrupting viral RNA replication and virion assembly.

2D Structure

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc(-c2ccc(-c3ccc(-c4cnc([C@@H]5CCCN5C(=O)[C@@H](NC(=O)OC)C(C)C)[nH]4)cc3)cc2)[nH]1)C(C)C.Cl.Cl

                

                

                
                

                    
InChI

                    
InChI=1S/C40H50N8O6.2ClH/c1-23(2)33(45-39(51)53-5)37(49)47-19-7-9-31(47)35-41-21-29(43-35)27-15-11-25(12-16-27)26-13-17-28(18-14-26)30-22-42-36(44-30)32-10-8-20-48(32)38(50)34(24(3)4)46-40(52)54-6;;/h11-18,21-24,31-34H,7-10,19-20H2,1-6H3,(H,41,43)(H,42,44)(H,45,51)(H,46,52);2*1H/t31-,32-,33-,34-;;/m0../s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C40H52Cl2N8O6

                    

                    
                    

                        
HBD / HBA

                        
6 / 8

                    

                    
                    

                        
Rotatable Bonds

                        
13

                    

                    
                    
                    

                        
Heavy Atoms

                        
56

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Frequently Asked Questions

                

                    
                    

                        
                        

                            
The dihydrochloride salt form of daclatasvir, a hepatitis C NS5A inhibitor used in combination antiviral regimens. The salt formulation provides improved stability and bioavailability.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits the NS5A protein of hepatitis C virus, disrupting viral RNA replication and virion assembly.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Daclatasvir Dihydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL2303621.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 25154713.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Medical Disclaimer

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.