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Dapagliflozin

CHEMBL429910 Phase 4 Approved Small molecule
Half-Life
12.9 hours
Bioavailability
—
Protein Binding
—
Molecular Weight
408.9 g/mol
LogP
2.3
Phase
4

An SGLT2 inhibitor that lowers blood sugar by blocking glucose reabsorption in the kidney, causing excess glucose to be excreted in urine, and has additional benefits for heart failure and chronic kidney disease regardless of diabetes status. It also promotes modest weight loss and blood pressure reduction.

Molecular Weight

408.8730 g/mol

LogP

2.30

TPSA

99.40 Ų

Lipinski RO5

Pass

Therapeutic Areas

Atrial Fibrillation Benign Prostatic Hyperplasia Bladder Cancer Breast Cancer Cardiovascular Disease Chronic Kidney Disease Colorectal Cancer Heart Failure Hypertension Inflammatory Bowel Disease Major Depressive Disorder Non-Alcoholic Fatty Liver Disease Non-Small Cell Lung Cancer Obesity Ovarian Cancer Pancreatic Cancer Prostate Cancer Schizophrenia Stroke Systemic Lupus Erythematosus Thyroid Cancer Type 2 Diabetes

Drug Classes

A — A - Alimentary Tract and Metabolism

Mechanism of Action

Selective SGLT2 inhibitor reducing renal glucose and sodium reabsorption.

Pharmacokinetics (PK)

Half-Life 12.9 hours

Pharmacodynamics (PD)

Mechanism

Selective SGLT2 inhibitor reducing renal glucose and sodium reabsorption.

2D Structure

SVG PNG

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SMILES

                    
CCOc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)cc1

                

                

                
                

                    
InChI

                    
InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C21H25ClO6

                    

                    
                    

                        
HBD / HBA

                        
4 / 6

                    

                    
                    

                        
Rotatable Bonds

                        
6

                    

                    
                    
                    

                        
Heavy Atoms

                        
28

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Frequently Asked Questions

                

                    
                    

                        
                        

                            
An SGLT2 inhibitor that lowers blood sugar by blocking glucose reabsorption in the kidney, causing excess glucose to be excreted in urine, and has additional benefits for heart failure and chronic kidney disease regardless of diabetes status. It also promotes modest weight loss and blood pressure reduction.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Selective SGLT2 inhibitor reducing renal glucose and sodium reabsorption.

                        

                    

                    

                    
                    

                        
                        

                            
Key pharmacokinetic parameters for Dapagliflozin: Half-life: 12.9 hours.

                        

                    

                    

                    

                        
                        

                            
Yes, Dapagliflozin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            
            

                
Related Drugs


                
                

                    
Same Drug Class

                    

                        
                        
                            Canagliflozin
                            Small molecule
                        
                        
                        
                            Dulaglutide
                            Protein
                        
                        
                        
                            Empagliflozin
                            Small molecule
                        
                        
                        
                            Esomeprazole
                            Small molecule
                        
                        
                    

                

                

                
            

            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
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                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL429910.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 9887712.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Medical Disclaimer

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.