Desonide
A low-potency topical corticosteroid used for mild-to-moderate inflammatory skin conditions including eczema and atopic dermatitis, and is considered safe enough for use on the face and skin folds. Its low potency makes it one of the preferred steroids for treating children and sensitive skin areas.
Molecular Weight
416.5000 g/mol
LogP
2.70
TPSA
93.10 Ų
Lipinski RO5
Pass
Therapeutic Areas
Mechanism of Action
Binds to intracellular glucocorticoid receptors, translocating to the nucleus to modulate gene transcription. This suppresses multiple inflammatory genes encoding cytokines, chemokines, and adhesion molecules while inducing anti-inflammatory proteins.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to intracellular glucocorticoid receptors, translocating to the nucleus to modulate gene transcription. This suppresses multiple inflammatory genes encoding cytokines, chemokines, and adhesion molecules while inducing anti-inflammatory proteins.
2D Structure
Cite this structure
Embed this structure
SMILES
CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1
InChI
InChI=1S/C24H32O6/c1-21(2)29-19-10-16-15-6-5-13-9-14(26)7-8-22(13,3)20(15)17(27)11-23(16,4)24(19,30-21)18(28)12-25/h7-9,15-17,19-20,25,27H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,20+,22-,23-,24+/m0/s1
Molecular Formula
C24H32O6
HBD / HBA
2 / 6
Rotatable Bonds
2
Heavy Atoms
30
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
A low-potency topical corticosteroid used for mild-to-moderate inflammatory skin conditions including eczema and atopic dermatitis, and is considered safe enough for use on the face and skin folds. Its low potency makes it one of the preferred steroids for treating children and sensitive skin areas.
Binds to intracellular glucocorticoid receptors, translocating to the nucleus to modulate gene transcription. This suppresses multiple inflammatory genes encoding cytokines, chemokines, and adhesion molecules while inducing anti-inflammatory proteins.
Yes, Desonide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201109. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5311066. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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