Dextrothyroxine Sodium

CHEMBL3545058 Phase 4 Approved Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

798.8 g/mol

LogP

—

Phase

4

The sodium salt of dextrothyroxine, a thyroid hormone isomer historically used as a cholesterol-lowering agent. It was withdrawn from the market after large trials revealed an unacceptable increase in cardiac events.

Molecular Weight

798.8500 g/mol

TPSA

95.60 Å²

Therapeutic Areas

Cardiovascular Disease

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

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SMILES

N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)[O-].O.[Na+]

InChI

InChI=1S/C15H11I4NO4.Na.H2O/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23;;/h1-2,4-5,12,21H,3,20H2,(H,22,23);;1H2/q;+1;/p-1/t12-;;/m1../s1

Molecular Formula

C15H10I4NNaO4

HBD / HBA

2 / 5

Rotatable Bonds

5

Heavy Atoms

25

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Frequently Asked Questions

The sodium salt of dextrothyroxine, a thyroid hormone isomer historically used as a cholesterol-lowering agent. It was withdrawn from the market after large trials revealed an unacceptable increase in cardiac events.

Yes, Dextrothyroxine Sodium is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3545058. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 23690433. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Structure

Quick Data

Formula: C15H10I4NNaO4

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Medical Disclaimer

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.