Echothiophate

CHEMBL1201341 Phase 4 Approved Small molecule
Half-Life
Bioavailability
Protein Binding
Molecular Weight
256.3 g/mol
LogP
1.0
Phase
4

An organophosphate cholinesterase inhibitor used as an eye drop to treat glaucoma and certain types of strabismus (crossed eyes). It reduces intraocular pressure by promoting the drainage of fluid from the eye.

Molecular Weight

256.3300 g/mol

LogP

1.00

TPSA

60.80 Ų

Lipinski RO5

Pass

Mechanism of Action

Inhibits acetylcholinesterase, the enzyme that hydrolyzes acetylcholine in the synaptic cleft. This increases acetylcholine availability at cholinergic synapses, enhancing cholinergic neurotransmission.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mechanism

Inhibits acetylcholinesterase, the enzyme that hydrolyzes acetylcholine in the synaptic cleft. This increases acetylcholine availability at cholinergic synapses, enhancing cholinergic neurotransmission.

2D Structure

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SMILES

CCOP(=O)(OCC)SCC[N+](C)(C)C

InChI

InChI=1S/C9H23NO3PS/c1-6-12-14(11,13-7-2)15-9-8-10(3,4)5/h6-9H2,1-5H3/q+1

Molecular Formula

C9H23NO3PS+

HBD / HBA

- / 4

Rotatable Bonds

8

Heavy Atoms

15

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Frequently Asked Questions

An organophosphate cholinesterase inhibitor used as an eye drop to treat glaucoma and certain types of strabismus (crossed eyes). It reduces intraocular pressure by promoting the drainage of fluid from the eye.

Inhibits acetylcholinesterase, the enzyme that hydrolyzes acetylcholine in the synaptic cleft. This increases acetylcholine availability at cholinergic synapses, enhancing cholinergic neurotransmission.

Yes, Echothiophate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

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References & Data Sources

  • ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201341. Open-access bioactivity database.
  • PubChem — National Center for Biotechnology Information (NCBI). CID 10548. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

Medical Disclaimer

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.