Eluxadoline
This medication works in the gut to reduce cramping and diarrhea by acting on opioid receptors in the intestinal lining. It is used to treat irritable bowel syndrome with diarrhea in adults.
Molecular Weight
569.6000 g/mol
LogP
0.90
TPSA
165.00 Ų
Lipinski RO5
Pass
Therapeutic Areas
Mechanism of Action
Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission …
2D Structure
Cite this structure
Embed this structure
SMILES
COc1ccc(CN(C(=O)[C@@H](N)Cc2c(C)cc(C(N)=O)cc2C)[C@@H](C)c2ncc(-c3ccccc3)[nH]2)cc1C(=O)O
InChI
InChI=1S/C32H35N5O5/c1-18-12-23(29(34)38)13-19(2)24(18)15-26(33)31(39)37(17-21-10-11-28(42-4)25(14-21)32(40)41)20(3)30-35-16-27(36-30)22-8-6-5-7-9-22/h5-14,16,20,26H,15,17,33H2,1-4H3,(H2,34,38)(H,35,36)(H,40,41)/t20-,26-/m0/s1
Molecular Formula
C32H35N5O5
HBD / HBA
4 / 7
Rotatable Bonds
11
Heavy Atoms
42
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
This medication works in the gut to reduce cramping and diarrhea by acting on opioid receptors in the intestinal lining. It is used to treat irritable bowel syndrome with diarrhea in adults.
Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.
Yes, Eluxadoline is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2159122. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 11250029. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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