Esketamine

CHEMBL395091 Phase 4 Approved Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

237.7 g/mol

LogP

2.2

Phase

4

This medication works rapidly on NMDA receptors in the brain to relieve symptoms of severe or treatment-resistant depression. Unlike traditional antidepressants, it can begin to reduce depressive symptoms within hours.

Molecular Weight

237.7200 g/mol

LogP

2.20

TPSA

29.10 Å²

Lipinski RO5

Pass

Therapeutic Areas

Bipolar Disorder Breast Cancer Chronic Pain Colorectal Cancer Endometriosis Generalized Anxiety Disorder Infectious Disease Insomnia Major Depressive Disorder Obesity Ovarian Cancer Pain Management Parkinson's Disease Schizophrenia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

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SMILES

CN[C@]1(c2ccccc2Cl)CCCCC1=O

InChI

InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3/t13-/m0/s1

Molecular Formula

C13H16ClNO

HBD / HBA

1 / 2

Rotatable Bonds

2

Heavy Atoms

16

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Frequently Asked Questions

This medication works rapidly on NMDA receptors in the brain to relieve symptoms of severe or treatment-resistant depression. Unlike traditional antidepressants, it can begin to reduce depressive symptoms within hours.

Yes, Esketamine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL395091. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 182137. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Structure

Quick Data

Formula: C13H16ClNO
Synonyms: 1

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Medical Disclaimer

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.