Etoposide Phosphate
The phosphate prodrug form of etoposide, this chemotherapy agent is converted in the body to active etoposide, which blocks DNA repair enzymes to kill cancer cells. The phosphate form improves water solubility for intravenous use.
Molecular Weight
668.5000 g/mol
LogP
-0.70
TPSA
207.00 Ų
Lipinski RO5
Fail
Therapeutic Areas
Mechanism of Action
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
2D Structure
Cite this structure
Embed this structure
SMILES
COc1cc([C@@H]2c3cc4c(cc3[C@@H](O[C@@H]3O[C@@H]5CO[C@@H](C)O[C@H]5[C@H](O)[C@H]3O)[C@H]3COC(=O)[C@H]23)OCO4)cc(OC)c1OP(=O)(O)O
InChI
InChI=1S/C29H33O16P/c1-11-38-9-20-27(42-11)23(30)24(31)29(43-20)44-25-14-7-17-16(40-10-41-17)6-13(14)21(22-15(25)8-39-28(22)32)12-4-18(36-2)26(19(5-12)37-3)45-46(33,34)35/h4-7,11,15,20-25,27,29-31H,8-10H2,1-3H3,(H2,33,34,35)/t11-,15+,20-,21-,22+,23-,24-,25-,27-,29+/m1/s1
Molecular Formula
C29H33O16P
HBD / HBA
4 / 16
Rotatable Bonds
7
Heavy Atoms
46
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
The phosphate prodrug form of etoposide, this chemotherapy agent is converted in the body to active etoposide, which blocks DNA repair enzymes to kill cancer cells. The phosphate form improves water solubility for intravenous use.
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Yes, Etoposide Phosphate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200645. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 6918092. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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