Fedratinib Hydrochloride

CHEMBL4297216 Phase 4 Approved Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

615.6 g/mol

LogP

—

Phase

4

The hydrochloride salt form of fedratinib, this JAK2 inhibitor blocks abnormal signaling that drives uncontrolled blood cell production in myelofibrosis. The salt form is used in the standard oral capsule formulation.

Molecular Weight

615.6000 g/mol

TPSA

118.00 Å²

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

SVG PNG

Cite this structure

Embed this structure

SMILES

Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1.Cl.Cl.O

InChI

InChI=1S/C27H36N6O3S.2ClH.H2O/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4;;;/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31);2*1H;1H2

Molecular Formula

C27H40Cl2N6O4S

HBD / HBA

6 / 10

Rotatable Bonds

11

Heavy Atoms

40

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Frequently Asked Questions

The hydrochloride salt form of fedratinib, this JAK2 inhibitor blocks abnormal signaling that drives uncontrolled blood cell production in myelofibrosis. The salt form is used in the standard oral capsule formulation.

Yes, Fedratinib Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4297216. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 67517580. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

PillFYI

Looking for patient-friendly information?

Fedratinib Hydrochloride on PillFYI

Structure

Quick Data

Formula: C27H40Cl2N6O4S
Synonyms: 1

External Links

Cite

BibTeX, APA, MLA, Chicago, IEEE, Harvard

Medical Disclaimer

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.