Fostamatinib

CHEMBL2103830 Phase 4 Approved Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

580.5 g/mol

LogP

1.6

Phase

4

This oral medication inhibits a signaling enzyme called SYK that is involved in the destruction of platelets by the immune system, helping to raise platelet counts in certain immune conditions. It is used to treat immune thrombocytopenia and has been studied in rheumatoid arthritis.

Molecular Weight

580.5000 g/mol

LogP

1.60

TPSA

187.00 Å²

Lipinski RO5

Fail

Therapeutic Areas

Leukemia Lymphoma Ovarian Cancer Rheumatoid Arthritis Systemic Lupus Erythematosus

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

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SMILES

COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)N(COP(=O)(O)O)C(=O)C(C)(C)O4)n2)cc(OC)c1OC

InChI

InChI=1S/C23H26FN6O9P/c1-23(2)21(31)30(11-38-40(32,33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4/h6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28,29)

Molecular Formula

C23H26FN6O9P

HBD / HBA

4 / 15

Rotatable Bonds

10

Heavy Atoms

40

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Frequently Asked Questions

This oral medication inhibits a signaling enzyme called SYK that is involved in the destruction of platelets by the immune system, helping to raise platelet counts in certain immune conditions. It is used to treat immune thrombocytopenia and has been studied in rheumatoid arthritis.

Yes, Fostamatinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2103830. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 11671467. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Structure

Quick Data

Formula: C23H26FN6O9P
Synonyms: 1

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Medical Disclaimer

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.