Gilteritinib Fumarate
A fumarate salt form of gilteritinib, an FLT3 inhibitor used to treat relapsed or refractory acute myeloid leukemia harboring FLT3 mutations. The fumarate salt form is the commercially available formulation used in clinical practice. It selectively targets FLT3-mutated leukemia cells, limiting harm to normal blood cell precursors.
Molecular Weight
1221.5000 g/mol
TPSA
317.00 Ų
Therapeutic Areas
Mechanism of Action
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
2D Structure
Cite this structure
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SMILES
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1.CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1.O=C(O)/C=C/C(=O)O
InChI
InChI=1S/2C29H44N8O3.C4H4O4/c2*1-4-23-28(31-20-9-17-40-18-10-20)34-29(26(33-23)27(30)38)32-21-5-6-24(25(19-21)39-3)37-11-7-22(8-12-37)36-15-13-35(2)14-16-36;5-3(6)1-2-4(7)8/h2*5-6,19-20,22H,4,7-18H2,1-3H3,(H2,30,38)(H2,31,32,34);1-2H,(H,5,6)(H,7,8)/b;;2-1+
Molecular Formula
C62H92N16O10
HBD / HBA
8 / 24
Rotatable Bonds
20
Heavy Atoms
88
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
A fumarate salt form of gilteritinib, an FLT3 inhibitor used to treat relapsed or refractory acute myeloid leukemia harboring FLT3 mutations. The fumarate salt form is the commercially available formulation used in clinical practice. It selectively targets FLT3-mutated leukemia cells, limiting harm to normal blood cell precursors.
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Yes, Gilteritinib Fumarate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3301603. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 76970819. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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