Guanadrel

CHEMBL1037 Phase 4 Approved Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

213.3 g/mol

LogP

—

Phase

4

An antihypertensive medication that works by depleting norepinephrine stores in sympathetic nerve terminals, reducing the ability of the nervous system to raise blood pressure. It was used in patients with moderate to severe hypertension who did not respond to first-line treatments. Due to significant side effects including orthostatic hypotension, it has largely been replaced by better-tolerated medications.

Molecular Weight

213.2800 g/mol

LogP

0.00

TPSA

82.90 Å²

Lipinski RO5

Pass

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

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SMILES

N=C(N)NCC1COC2(CCCCC2)O1

InChI

InChI=1S/C10H19N3O2/c11-9(12)13-6-8-7-14-10(15-8)4-2-1-3-5-10/h8H,1-7H2,(H4,11,12,13)

Molecular Formula

C10H19N3O2

HBD / HBA

2 / 3

Rotatable Bonds

2

Heavy Atoms

15

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Frequently Asked Questions

An antihypertensive medication that works by depleting norepinephrine stores in sympathetic nerve terminals, reducing the ability of the nervous system to raise blood pressure. It was used in patients with moderate to severe hypertension who did not respond to first-line treatments. Due to significant side effects including orthostatic hypotension, it has largely been replaced by better-tolerated medications.

Yes, Guanadrel is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1037. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 38521. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Structure

Quick Data

Formula: C10H19N3O2

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Medical Disclaimer

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.