Guanethidine Monosulfate

CHEMBL1345 Phase 4 Approved Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

296.4 g/mol

LogP

—

Phase

4

A monosulfate salt form of guanethidine, an antihypertensive that blocks norepinephrine release from sympathetic neurons to lower blood pressure in patients with difficult-to-control hypertension. This salt form is the pharmaceutical preparation used in clinical practice. Its use requires careful management of orthostatic hypotension and drug interactions.

Molecular Weight

296.3900 g/mol

TPSA

151.00 Å²

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

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SMILES

N=C(N)NCCN1CCCCCCC1.O=S(=O)(O)O

InChI

InChI=1S/C10H22N4.H2O4S/c11-10(12)13-6-9-14-7-4-2-1-3-5-8-14;1-5(2,3)4/h1-9H2,(H4,11,12,13);(H2,1,2,3,4)

Molecular Formula

C10H24N4O4S

HBD / HBA

4 / 6

Rotatable Bonds

3

Heavy Atoms

19

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Frequently Asked Questions

A monosulfate salt form of guanethidine, an antihypertensive that blocks norepinephrine release from sympathetic neurons to lower blood pressure in patients with difficult-to-control hypertension. This salt form is the pharmaceutical preparation used in clinical practice. Its use requires careful management of orthostatic hypotension and drug interactions.

Yes, Guanethidine Monosulfate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1345. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 86471. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Structure

Quick Data

Formula: C10H24N4O4S

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Medical Disclaimer

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.