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Hydrocortisone Probutate

CHEMBL1200953 Phase 4 Approved Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
488.6 g/mol
LogP
4.2
Phase
4

A unique double-ester derivative of hydrocortisone designed to improve skin penetration and local anti-inflammatory potency while minimizing systemic absorption. It is used as a topical corticosteroid for inflammatory skin conditions. Once absorbed into the skin, it is metabolized to active hydrocortisone to exert its therapeutic effect.

Molecular Weight

488.6000 g/mol

LogP

4.20

TPSA

107.00 Ų

Lipinski RO5

Pass

Therapeutic Areas

Asthma Atopic Dermatitis Atrial Fibrillation Benign Prostatic Hyperplasia Bladder Cancer Breast Cancer Chronic Obstructive Pulmonary Disease Chronic Pain Colorectal Cancer Generalized Anxiety Disorder Glaucoma Gout Heart Failure HIV/AIDS Hypertension Inflammatory Bowel Disease Insomnia Leukemia Lymphoma Major Depressive Disorder Melanoma Multiple Sclerosis Non-Small Cell Lung Cancer Obesity Ovarian Cancer Pain Management Pancreatic Cancer Parkinson's Disease Prostate Cancer Psoriasis Rheumatoid Arthritis Stroke Systemic Lupus Erythematosus Thyroid Cancer Tuberculosis Type 2 Diabetes

Mechanism of Action

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mechanism

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

2D Structure

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CCCC(=O)O[C@]1(C(=O)COC(=O)CC)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C

                

                

                
                

                    
InChI

                    
InChI=1S/C28H40O7/c1-5-7-24(33)35-28(22(31)16-34-23(32)6-2)13-11-20-19-9-8-17-14-18(29)10-12-26(17,3)25(19)21(30)15-27(20,28)4/h14,19-21,25,30H,5-13,15-16H2,1-4H3/t19-,20-,21-,25+,26-,27-,28-/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C28H40O7

                    

                    
                    

                        
HBD / HBA

                        
1 / 7

                    

                    
                    

                        
Rotatable Bonds

                        
9

                    

                    
                    
                    

                        
Heavy Atoms

                        
35

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Frequently Asked Questions

                

                    
                    

                        
                        

                            
A unique double-ester derivative of hydrocortisone designed to improve skin penetration and local anti-inflammatory potency while minimizing systemic absorption. It is used as a topical corticosteroid for inflammatory skin conditions. Once absorbed into the skin, it is metabolized to active hydrocortisone to exert its therapeutic effect.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Hydrocortisone Probutate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1200953.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 636398.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Medical Disclaimer

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.