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Hydrocortisone Sodium Phosphate

CHEMBL1200968 Phase 4 Approved Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
486.4 g/mol
LogP
—
Phase
4

A water-soluble sodium phosphate salt form of hydrocortisone used in injectable formulations for the acute treatment of severe allergic reactions, asthma attacks, adrenal crisis, and severe inflammation. Its high solubility allows rapid intravenous or intramuscular administration in emergency situations. This formulation provides fast onset of corticosteroid effect when oral treatment is not feasible.

Molecular Weight

486.4000 g/mol

TPSA

147.00 Ų

Therapeutic Areas

Asthma Atopic Dermatitis Atrial Fibrillation Benign Prostatic Hyperplasia Bladder Cancer Breast Cancer Chronic Obstructive Pulmonary Disease Chronic Pain Colorectal Cancer Generalized Anxiety Disorder Glaucoma Gout Heart Failure HIV/AIDS Hypertension Inflammatory Bowel Disease Insomnia Leukemia Lymphoma Major Depressive Disorder Melanoma Multiple Sclerosis Non-Small Cell Lung Cancer Obesity Ovarian Cancer Pain Management Pancreatic Cancer Parkinson's Disease Prostate Cancer Psoriasis Rheumatoid Arthritis Stroke Systemic Lupus Erythematosus Thyroid Cancer Tuberculosis Type 2 Diabetes

Mechanism of Action

Binds to intracellular glucocorticoid receptors, translocating to the nucleus to modulate gene transcription. This suppresses multiple inflammatory genes encoding cytokines, chemokines, and adhesion molecules while inducing anti-inflammatory proteins.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mechanism

Binds to intracellular glucocorticoid receptors, translocating to the nucleus to modulate gene transcription. This suppresses multiple inflammatory genes encoding cytokines, chemokines, and adhesion molecules while inducing anti-inflammatory proteins.

2D Structure

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)COP(=O)([O-])[O-].[Na+].[Na+]

                

                

                
                

                    
InChI

                    
InChI=1S/C21H31O8P.2Na/c1-19-7-5-13(22)9-12(19)3-4-14-15-6-8-21(25,17(24)11-29-30(26,27)28)20(15,2)10-16(23)18(14)19;;/h9,14-16,18,23,25H,3-8,10-11H2,1-2H3,(H2,26,27,28);;/q;2*+1/p-2/t14-,15-,16-,18+,19-,20-,21-;;/m0../s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C21H29Na2O8P

                    

                    
                    

                        
HBD / HBA

                        
2 / 8

                    

                    
                    

                        
Rotatable Bonds

                        
3

                    

                    
                    
                    

                        
Heavy Atoms

                        
32

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Frequently Asked Questions

                

                    
                    

                        
                        

                            
A water-soluble sodium phosphate salt form of hydrocortisone used in injectable formulations for the acute treatment of severe allergic reactions, asthma attacks, adrenal crisis, and severe inflammation. Its high solubility allows rapid intravenous or intramuscular administration in emergency situations. This formulation provides fast onset of corticosteroid effect when oral treatment is not feasible.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Binds to intracellular glucocorticoid receptors, translocating to the nucleus to modulate gene transcription. This suppresses multiple inflammatory genes encoding cytokines, chemokines, and adhesion molecules while inducing anti-inflammatory proteins.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Hydrocortisone Sodium Phosphate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1200968.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 441406.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Medical Disclaimer

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.