Lifitegrast
An integrin antagonist eye drop used to treat the signs and symptoms of dry eye disease. It works by blocking the LFA-1/ICAM-1 interaction that drives inflammation on the surface of the eye.
Molecular Weight
615.5000 g/mol
LogP
4.70
TPSA
142.00 Ų
Lipinski RO5
Pass
Therapeutic Areas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
2D Structure
Cite this structure
Embed this structure
SMILES
CS(=O)(=O)c1cccc(C[C@H](NC(=O)c2c(Cl)cc3c(c2Cl)CCN(C(=O)c2ccc4ccoc4c2)C3)C(=O)O)c1
InChI
InChI=1S/C29H24Cl2N2O7S/c1-41(38,39)20-4-2-3-16(11-20)12-23(29(36)37)32-27(34)25-22(30)13-19-15-33(9-7-21(19)26(25)31)28(35)18-6-5-17-8-10-40-24(17)14-18/h2-6,8,10-11,13-14,23H,7,9,12,15H2,1H3,(H,32,34)(H,36,37)/t23-/m0/s1
Molecular Formula
C29H24Cl2N2O7S
HBD / HBA
2 / 7
Rotatable Bonds
7
Heavy Atoms
41
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
An integrin antagonist eye drop used to treat the signs and symptoms of dry eye disease. It works by blocking the LFA-1/ICAM-1 interaction that drives inflammation on the surface of the eye.
Yes, Lifitegrast is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2048028. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 11965427. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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