Lonafarnib

CHEMBL298734 Phase 4 Approved Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

638.8 g/mol

LogP

4.8

Phase

4

A farnesyltransferase inhibitor used to treat Hutchinson-Gilford progeria syndrome, a rare premature aging condition, and studied in hepatitis D infection. It blocks the processing of a defective protein that causes rapid cellular aging in progeria patients.

Molecular Weight

638.8000 g/mol

LogP

4.80

TPSA

79.50 Å²

Lipinski RO5

Pass

Therapeutic Areas

Bladder Cancer Breast Cancer Colorectal Cancer Leukemia Lymphoma Non-Alcoholic Fatty Liver Disease Non-Small Cell Lung Cancer Ovarian Cancer Pancreatic Cancer Prostate Cancer Thyroid Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

SVG PNG

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SMILES

NC(=O)N1CCC(CC(=O)N2CCC([C@H]3c4ncc(Br)cc4CCc4cc(Cl)cc(Br)c43)CC2)CC1

InChI

InChI=1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36)/t25-/m1/s1

Molecular Formula

C27H31Br2ClN4O2

HBD / HBA

1 / 3

Rotatable Bonds

3

Heavy Atoms

36

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Frequently Asked Questions

A farnesyltransferase inhibitor used to treat Hutchinson-Gilford progeria syndrome, a rare premature aging condition, and studied in hepatitis D infection. It blocks the processing of a defective protein that causes rapid cellular aging in progeria patients.

Yes, Lonafarnib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL298734. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 148195. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Structure

Quick Data

Formula: C27H31Br2ClN4O2
Synonyms: 1

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Medical Disclaimer

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.