Loperamide
An opioid receptor agonist acting locally in the gut, used to treat diarrhea including traveler's diarrhea and diarrhea associated with inflammatory bowel disease. It slows intestinal motility and reduces fluid loss without crossing the blood-brain barrier in therapeutic doses.
Molecular Weight
477.0000 g/mol
LogP
5.00
TPSA
43.80 Ų
Lipinski RO5
Pass
Therapeutic Areas
Mechanism of Action
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
2D Structure
Cite this structure
Embed this structure
SMILES
CN(C)C(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1
InChI
InChI=1S/C29H33ClN2O2/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23/h3-16,34H,17-22H2,1-2H3
Molecular Formula
C29H33ClN2O2
HBD / HBA
1 / 3
Rotatable Bonds
7
Heavy Atoms
34
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
An opioid receptor agonist acting locally in the gut, used to treat diarrhea including traveler's diarrhea and diarrhea associated with inflammatory bowel disease. It slows intestinal motility and reduces fluid loss without crossing the blood-brain barrier in therapeutic doses.
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Yes, Loperamide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL841. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 3955. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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