Lotilaner

CHEMBL3707310 Phase 4 Approved Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

596.8 g/mol

LogP

6.6

Phase

4

This isoxazoline compound kills parasites like fleas and ticks on companion animals by blocking insect-specific chloride channels, causing paralysis and death of the parasites. It is used in oral or ophthalmic formulations for veterinary and some human parasitic infections.

Molecular Weight

596.8000 g/mol

LogP

6.60

TPSA

108.00 Å²

Lipinski RO5

Fail

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

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SMILES

Cc1cc(C2=NO[C@@](c3cc(Cl)c(Cl)c(Cl)c3)(C(F)(F)F)C2)sc1C(=O)NCC(=O)NCC(F)(F)F

InChI

InChI=1S/C20H14Cl3F6N3O3S/c1-8-2-13(36-16(8)17(34)30-6-14(33)31-7-19(24,25)26)12-5-18(35-32-12,20(27,28)29)9-3-10(21)15(23)11(22)4-9/h2-4H,5-7H2,1H3,(H,30,34)(H,31,33)/t18-/m0/s1

Molecular Formula

C20H14Cl3F6N3O3S

HBD / HBA

2 / 11

Rotatable Bonds

6

Heavy Atoms

36

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Frequently Asked Questions

This isoxazoline compound kills parasites like fleas and ticks on companion animals by blocking insect-specific chloride channels, causing paralysis and death of the parasites. It is used in oral or ophthalmic formulations for veterinary and some human parasitic infections.

Yes, Lotilaner is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3707310. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 76959255. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Structure

Quick Data

Formula: C20H14Cl3F6N3O3S
Synonyms: 3

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Medical Disclaimer

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.