Lumefantrine
This antimalarial drug is used exclusively in combination with artemether to treat uncomplicated malaria caused by Plasmodium falciparum, including strains resistant to older drugs like chloroquine. It works by accumulating in infected red blood cells and interfering with the parasite's ability to detoxify heme, a byproduct of its digestion of hemoglobin.
Molecular Weight
528.9000 g/mol
LogP
8.70
TPSA
23.50 Ų
Lipinski RO5
Fail
Therapeutic Areas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
2D Structure
Cite this structure
Embed this structure
SMILES
CCCCN(CCCC)CC(O)c1cc(Cl)cc2c1-c1ccc(Cl)cc1/C2=C/c1ccc(Cl)cc1
InChI
InChI=1S/C30H32Cl3NO/c1-3-5-13-34(14-6-4-2)19-29(35)28-18-23(33)17-27-25(15-20-7-9-21(31)10-8-20)26-16-22(32)11-12-24(26)30(27)28/h7-12,15-18,29,35H,3-6,13-14,19H2,1-2H3/b25-15-
Molecular Formula
C30H32Cl3NO
HBD / HBA
1 / 2
Rotatable Bonds
10
Heavy Atoms
35
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
This antimalarial drug is used exclusively in combination with artemether to treat uncomplicated malaria caused by Plasmodium falciparum, including strains resistant to older drugs like chloroquine. It works by accumulating in infected red blood cells and interfering with the parasite's ability to detoxify heme, a byproduct of its digestion of hemoglobin.
Yes, Lumefantrine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL38827. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 6437380. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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