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Mechlorethamine Hydrochloride

CHEMBL1201001 Phase 4 Approved Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
192.5 g/mol
LogP
—
Phase
4

A hydrochloride salt form of mechlorethamine, a nitrogen mustard chemotherapy drug used to treat Hodgkin lymphoma, certain other lymphomas, and mycosis fungoides by damaging the DNA of rapidly dividing cancer cells.

Molecular Weight

192.5000 g/mol

TPSA

3.20 Ų

Therapeutic Areas

Bladder Cancer Breast Cancer Chronic Pain Colorectal Cancer Leukemia Lymphoma Melanoma Multiple Sclerosis Non-Small Cell Lung Cancer Ovarian Cancer Pain Management Pancreatic Cancer Prostate Cancer Rheumatoid Arthritis Systemic Lupus Erythematosus Thyroid Cancer

Mechanism of Action

Forms covalent bonds with DNA bases, creating cross-links and strand breaks that prevent DNA replication and transcription. This triggers apoptosis in rapidly dividing cells, particularly cancer cells.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mechanism

Forms covalent bonds with DNA bases, creating cross-links and strand breaks that prevent DNA replication and transcription. This triggers apoptosis in rapidly dividing cells, particularly cancer cells.

2D Structure

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CN(CCCl)CCCl.Cl

                

                

                
                

                    
InChI

                    
InChI=1S/C5H11Cl2N.ClH/c1-8(4-2-6)5-3-7;/h2-5H2,1H3;1H

                

                

                

                    
                    

                        
Molecular Formula

                        
C5H12Cl3N

                    

                    
                    

                        
HBD / HBA

                        
1 / 1

                    

                    
                    

                        
Rotatable Bonds

                        
4

                    

                    
                    
                    

                        
Heavy Atoms

                        
9

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Frequently Asked Questions

                

                    
                    

                        
                        

                            
A hydrochloride salt form of mechlorethamine, a nitrogen mustard chemotherapy drug used to treat Hodgkin lymphoma, certain other lymphomas, and mycosis fungoides by damaging the DNA of rapidly dividing cancer cells.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Forms covalent bonds with DNA bases, creating cross-links and strand breaks that prevent DNA replication and transcription. This triggers apoptosis in rapidly dividing cells, particularly cancer cells.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Mechlorethamine Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1201001.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5935.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Medical Disclaimer

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.