Mechlorethamine
A nitrogen mustard alkylating agent used as a chemotherapy treatment for certain blood cancers including Hodgkin lymphoma and mycosis fungoides, working by cross-linking DNA strands to prevent cancer cell replication. It is one of the oldest chemotherapy drugs still in use today.
Molecular Weight
156.0500 g/mol
LogP
0.90
TPSA
3.20 Ų
Lipinski RO5
Pass
Therapeutic Areas
Mechanism of Action
Forms covalent bonds with DNA bases, creating cross-links and strand breaks that prevent DNA replication and transcription. This triggers apoptosis in rapidly dividing cells, particularly cancer cells.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Forms covalent bonds with DNA bases, creating cross-links and strand breaks that prevent DNA replication and transcription. This triggers apoptosis in rapidly dividing cells, particularly cancer cells.
2D Structure
Cite this structure
Embed this structure
SMILES
CN(CCCl)CCCl
InChI
InChI=1S/C5H11Cl2N/c1-8(4-2-6)5-3-7/h2-5H2,1H3
Molecular Formula
C5H11Cl2N
HBD / HBA
- / 1
Rotatable Bonds
4
Heavy Atoms
8
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
A nitrogen mustard alkylating agent used as a chemotherapy treatment for certain blood cancers including Hodgkin lymphoma and mycosis fungoides, working by cross-linking DNA strands to prevent cancer cell replication. It is one of the oldest chemotherapy drugs still in use today.
Forms covalent bonds with DNA bases, creating cross-links and strand breaks that prevent DNA replication and transcription. This triggers apoptosis in rapidly dividing cells, particularly cancer cells.
Yes, Mechlorethamine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL427. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 4033. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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