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Metabromsalan

CHEMBL1801800 Phase 4 Approved Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
371.0 g/mol
LogP
4.3
Phase
4

This halogenated salicylanilide compound was used as an antiseptic and disinfectant in soaps and skin preparations to kill bacteria and fungi. It was withdrawn from use in many countries due to phototoxicity reactions and the risk of cross-sensitization with other antimicrobial agents.

Molecular Weight

371.0200 g/mol

LogP

4.30

TPSA

49.30 Ų

Lipinski RO5

Pass

Mechanism of Action

Disrupts microbial cell membranes and denatures proteins on contact, producing rapid broad-spectrum antimicrobial activity on skin and wound surfaces.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mechanism

Disrupts microbial cell membranes and denatures proteins on contact, producing rapid broad-spectrum antimicrobial activity on skin and wound surfaces.

2D Structure

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
O=C(Nc1ccccc1)c1cc(Br)cc(Br)c1O

                

                

                
                

                    
InChI

                    
InChI=1S/C13H9Br2NO2/c14-8-6-10(12(17)11(15)7-8)13(18)16-9-4-2-1-3-5-9/h1-7,17H,(H,16,18)

                

                

                

                    
                    

                        
Molecular Formula

                        
C13H9Br2NO2

                    

                    
                    

                        
HBD / HBA

                        
2 / 2

                    

                    
                    

                        
Rotatable Bonds

                        
2

                    

                    
                    
                    

                        
Heavy Atoms

                        
18

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Frequently Asked Questions

                

                    
                    

                        
                        

                            
This halogenated salicylanilide compound was used as an antiseptic and disinfectant in soaps and skin preparations to kill bacteria and fungi. It was withdrawn from use in many countries due to phototoxicity reactions and the risk of cross-sensitization with other antimicrobial agents.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Disrupts microbial cell membranes and denatures proteins on contact, producing rapid broad-spectrum antimicrobial activity on skin and wound surfaces.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Metabromsalan is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1801800.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 17404.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Medical Disclaimer

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.