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Midodrine

CHEMBL1201212 Phase 4 Approved Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
254.3 g/mol
LogP
-0.6
Phase
4

This medication works by tightening blood vessels to raise blood pressure in people whose pressure drops too low when they stand up. It is used to treat a condition called orthostatic hypotension, which causes dizziness or fainting upon standing.

Molecular Weight

254.2800 g/mol

LogP

-0.60

TPSA

93.80 Ų

Lipinski RO5

Pass

Therapeutic Areas

Heart Failure Hypertension Non-Alcoholic Fatty Liver Disease Parkinson's Disease Stroke

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

SVG PNG

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SMILES

                    
COc1ccc(OC)c(C(O)CNC(=O)CN)c1

                

                

                
                

                    
InChI

                    
InChI=1S/C12H18N2O4/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16)

                

                

                

                    
                    

                        
Molecular Formula

                        
C12H18N2O4

                    

                    
                    

                        
HBD / HBA

                        
3 / 5

                    

                    
                    

                        
Rotatable Bonds

                        
6

                    

                    
                    
                    

                        
Heavy Atoms

                        
18

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Frequently Asked Questions

                

                    
                    

                        
                        

                            
This medication works by tightening blood vessels to raise blood pressure in people whose pressure drops too low when they stand up. It is used to treat a condition called orthostatic hypotension, which causes dizziness or fainting upon standing.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Midodrine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1201212.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 4195.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Medical Disclaimer

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.