Mizolastine
This antihistamine blocks histamine receptors to relieve allergy symptoms such as sneezing, itching, and hives, while having fewer sedating effects than older antihistamines. It is used to treat seasonal allergies and chronic skin conditions like urticaria.
Molecular Weight
432.5000 g/mol
LogP
3.20
TPSA
65.80 Ų
Lipinski RO5
Pass
Mechanism of Action
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
2D Structure
Cite this structure
Embed this structure
SMILES
CN(c1nccc(=O)[nH]1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1
InChI
InChI=1S/C24H25FN6O/c1-29(23-26-13-10-22(32)28-23)19-11-14-30(15-12-19)24-27-20-4-2-3-5-21(20)31(24)16-17-6-8-18(25)9-7-17/h2-10,13,19H,11-12,14-16H2,1H3,(H,26,28,32)
Molecular Formula
C24H25FN6O
HBD / HBA
1 / 5
Rotatable Bonds
5
Heavy Atoms
32
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
This antihistamine blocks histamine receptors to relieve allergy symptoms such as sneezing, itching, and hives, while having fewer sedating effects than older antihistamines. It is used to treat seasonal allergies and chronic skin conditions like urticaria.
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Yes, Mizolastine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL94454. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 65906. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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