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Olutasidenib

CHEMBL4297610 Phase 4 Approved Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
354.8 g/mol
LogP
2.5
Phase
4

An inhibitor of mutant isocitrate dehydrogenase 1 (IDH1) used to treat relapsed or refractory acute myeloid leukemia (AML) in adults with an IDH1 mutation. It works by blocking the abnormal enzyme, reducing production of the oncometabolite 2-hydroxyglutarate and allowing leukemia cells to mature normally.

Molecular Weight

354.8000 g/mol

LogP

2.50

TPSA

85.20 Ų

Lipinski RO5

Pass

Therapeutic Areas

Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

SVG PNG

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SMILES

                    
C[C@H](Nc1ccc(C#N)n(C)c1=O)c1cc2cc(Cl)ccc2[nH]c1=O

                

                

                
                

                    
InChI

                    
InChI=1S/C18H15ClN4O2/c1-10(21-16-6-4-13(9-20)23(2)18(16)25)14-8-11-7-12(19)3-5-15(11)22-17(14)24/h3-8,10,21H,1-2H3,(H,22,24)/t10-/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C18H15ClN4O2

                    

                    
                    

                        
HBD / HBA

                        
2 / 4

                    

                    
                    

                        
Rotatable Bonds

                        
3

                    

                    
                    
                    

                        
Heavy Atoms

                        
25

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Frequently Asked Questions

                

                    
                    

                        
                        

                            
An inhibitor of mutant isocitrate dehydrogenase 1 (IDH1) used to treat relapsed or refractory acute myeloid leukemia (AML) in adults with an IDH1 mutation. It works by blocking the abnormal enzyme, reducing production of the oncometabolite 2-hydroxyglutarate and allowing leukemia cells to mature normally.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Olutasidenib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL4297610.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 118955396.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Medical Disclaimer

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.