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Omidenepag Isopropyl

CHEMBL4297666 Phase 4 Approved Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
520.6 g/mol
LogP
3.0
Phase
4

A selective prostaglandin EP2 receptor agonist eye drop used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension. It works through a different receptor pathway than traditional prostaglandin analogs, increasing the drainage of fluid from the eye.

Molecular Weight

520.6000 g/mol

LogP

3.00

TPSA

128.00 Ų

Lipinski RO5

Pass

Therapeutic Areas

Glaucoma Hypertension

Mechanism of Action

Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mechanism

Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.

2D Structure

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CC(C)OC(=O)CNc1cccc(CN(Cc2ccc(-n3cccn3)cc2)S(=O)(=O)c2cccnc2)n1

                

                

                
                

                    
InChI

                    
InChI=1S/C26H28N6O4S/c1-20(2)36-26(33)17-28-25-8-3-6-22(30-25)19-31(37(34,35)24-7-4-13-27-16-24)18-21-9-11-23(12-10-21)32-15-5-14-29-32/h3-16,20H,17-19H2,1-2H3,(H,28,30)

                

                

                

                    
                    

                        
Molecular Formula

                        
C26H28N6O4S

                    

                    
                    

                        
HBD / HBA

                        
1 / 9

                    

                    
                    

                        
Rotatable Bonds

                        
12

                    

                    
                    
                    

                        
Heavy Atoms

                        
37

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Frequently Asked Questions

                

                    
                    

                        
                        

                            
A selective prostaglandin EP2 receptor agonist eye drop used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension. It works through a different receptor pathway than traditional prostaglandin analogs, increasing the drainage of fluid from the eye.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Omidenepag Isopropyl is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL4297666.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 44230999.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Medical Disclaimer

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.