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Pentoxifylline

CHEMBL628 Phase 4 Approved Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
278.3 g/mol
LogP
0.3
Phase
4

This medication improves blood flow by making red blood cells more flexible, used for intermittent claudication.

Molecular Weight

278.3100 g/mol

LogP

0.30

TPSA

75.50 Ų

Lipinski RO5

Pass

Therapeutic Areas

Breast Cancer Cardiovascular Disease Chronic Kidney Disease Colorectal Cancer Endometriosis Epilepsy Heart Failure Hepatitis C HIV/AIDS Inflammatory Bowel Disease Leukemia Lymphoma Major Depressive Disorder Malaria Non-Alcoholic Fatty Liver Disease Non-Small Cell Lung Cancer Obesity Prostate Cancer Rheumatoid Arthritis Schizophrenia Systemic Lupus Erythematosus Type 2 Diabetes

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CC(=O)CCCCn1c(=O)c2c(ncn2C)n(C)c1=O

                

                

                
                

                    
InChI

                    
InChI=1S/C13H18N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8H,4-7H2,1-3H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C13H18N4O3

                    

                    
                    

                        
HBD / HBA

                        
- / 4

                    

                    
                    

                        
Rotatable Bonds

                        
5

                    

                    
                    
                    

                        
Heavy Atoms

                        
20

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Frequently Asked Questions

                

                    
                    

                        
                        

                            
This medication improves blood flow by making red blood cells more flexible, used for intermittent claudication.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Pentoxifylline is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL628.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 4740.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Medical Disclaimer

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.