Phenol
Phenol is a simple aromatic compound with antiseptic, disinfectant, local anesthetic, and cauterizing properties that acts by denaturing proteins and disrupting cell membranes at bactericidal concentrations. At low concentrations it has been used in throat sprays, ear drops, and topical analgesics, while at higher concentrations it serves as a chemical denervation and neurolytic agent in pain management procedures.
Molecular Weight
94.1100 g/mol
LogP
1.50
TPSA
20.20 Ų
Lipinski RO5
Pass
Therapeutic Areas
Mechanism of Action
Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.
2D Structure
Cite this structure
Embed this structure
SMILES
Oc1ccccc1
InChI
InChI=1S/C6H6O/c7-6-4-2-1-3-5-6/h1-5,7H
Molecular Formula
C6H6O
HBD / HBA
1 / 1
Rotatable Bonds
0
Heavy Atoms
7
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
Phenol is a simple aromatic compound with antiseptic, disinfectant, local anesthetic, and cauterizing properties that acts by denaturing proteins and disrupting cell membranes at bactericidal concentrations. At low concentrations it has been used in throat sprays, ear drops, and topical analgesics, while at higher concentrations it serves as a chemical denervation and neurolytic agent in pain management procedures.
Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.
Yes, Phenol is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL14060. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 996. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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