Pipobroman
Pipobroman is an alkylating antineoplastic agent structurally related to busulfan that exerts its cytotoxic effects by cross-linking DNA strands, thereby inhibiting DNA replication and inducing cell death in rapidly dividing cells. It has been used in the treatment of polycythemia vera and essential thrombocythemia as a myelosuppressive agent.
Molecular Weight
356.0500 g/mol
LogP
0.40
TPSA
40.60 Ų
Lipinski RO5
Pass
Pharmacokinetics (PK)
Pharmacodynamics (PD)
2D Structure
Cite this structure
Embed this structure
SMILES
O=C(CCBr)N1CCN(C(=O)CCBr)CC1
InChI
InChI=1S/C10H16Br2N2O2/c11-3-1-9(15)13-5-7-14(8-6-13)10(16)2-4-12/h1-8H2
Molecular Formula
C10H16Br2N2O2
HBD / HBA
- / 2
Rotatable Bonds
4
Heavy Atoms
16
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
Pipobroman is an alkylating antineoplastic agent structurally related to busulfan that exerts its cytotoxic effects by cross-linking DNA strands, thereby inhibiting DNA replication and inducing cell death in rapidly dividing cells. It has been used in the treatment of polycythemia vera and essential thrombocythemia as a myelosuppressive agent.
Yes, Pipobroman is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1585. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 4842. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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