Pirtobrutinib
Pirtobrutinib is a highly selective, non-covalent (reversible) Bruton's tyrosine kinase (BTK) inhibitor that blocks BTK-mediated B-cell receptor signaling essential for the survival and proliferation of malignant B cells. It is approved for the treatment of relapsed or refractory mantle cell lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma, including cases that have progressed on covalent BTK inhibitors.
Molecular Weight
479.4000 g/mol
LogP
3.30
TPSA
125.00 Ų
Lipinski RO5
Pass
Therapeutic Areas
Mechanism of Action
Irreversibly inhibits Bruton's tyrosine kinase (BTK), a key enzyme in the B-cell receptor signaling pathway that drives the survival and proliferation of malignant B cells.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Irreversibly inhibits Bruton's tyrosine kinase (BTK), a key enzyme in the B-cell receptor signaling pathway that drives the survival and proliferation of malignant B cells.
2D Structure
Cite this structure
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SMILES
COc1ccc(F)cc1C(=O)NCc1ccc(-c2nn([C@@H](C)C(F)(F)F)c(N)c2C(N)=O)cc1
InChI
InChI=1S/C22H21F4N5O3/c1-11(22(24,25)26)31-19(27)17(20(28)32)18(30-31)13-5-3-12(4-6-13)10-29-21(33)15-9-14(23)7-8-16(15)34-2/h3-9,11H,10,27H2,1-2H3,(H2,28,32)(H,29,33)/t11-/m0/s1
Molecular Formula
C22H21F4N5O3
HBD / HBA
3 / 9
Rotatable Bonds
7
Heavy Atoms
34
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
Pirtobrutinib is a highly selective, non-covalent (reversible) Bruton's tyrosine kinase (BTK) inhibitor that blocks BTK-mediated B-cell receptor signaling essential for the survival and proliferation of malignant B cells. It is approved for the treatment of relapsed or refractory mantle cell lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma, including cases that have progressed on covalent BTK inhibitors.
Irreversibly inhibits Bruton's tyrosine kinase (BTK), a key enzyme in the B-cell receptor signaling pathway that drives the survival and proliferation of malignant B cells.
Yes, Pirtobrutinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4650485. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 129269915. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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