Propanidid

CHEMBL2105345 Phase 4 Approved Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

337.4 g/mol

LogP

2.8

Phase

4

Propanidid is a short-acting intravenous anesthetic agent of the eugenol ester class that causes rapid loss of consciousness through CNS depression, likely through GABA-A receptor potentiation and other membrane effects, with an ultrashort duration of action due to rapid hydrolysis by plasma cholinesterases. It was withdrawn from clinical use in many countries due to a high incidence of anaphylactic reactions attributed to its solvent, cremophor EL.

Molecular Weight

337.4000 g/mol

LogP

2.80

TPSA

65.10 Å²

Lipinski RO5

Pass

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

SVG PNG

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SMILES

CCCOC(=O)Cc1ccc(OCC(=O)N(CC)CC)c(OC)c1

InChI

InChI=1S/C18H27NO5/c1-5-10-23-18(21)12-14-8-9-15(16(11-14)22-4)24-13-17(20)19(6-2)7-3/h8-9,11H,5-7,10,12-13H2,1-4H3

Molecular Formula

C18H27NO5

HBD / HBA

- / 5

Rotatable Bonds

11

Heavy Atoms

24

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Frequently Asked Questions

Propanidid is a short-acting intravenous anesthetic agent of the eugenol ester class that causes rapid loss of consciousness through CNS depression, likely through GABA-A receptor potentiation and other membrane effects, with an ultrashort duration of action due to rapid hydrolysis by plasma cholinesterases. It was withdrawn from clinical use in many countries due to a high incidence of anaphylactic reactions attributed to its solvent, cremophor EL.

Yes, Propanidid is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2105345. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 15004. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Structure

Quick Data

Formula: C18H27NO5

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Medical Disclaimer

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.