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Proparacaine

CHEMBL1196 Phase 4 Approved Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
294.4 g/mol
LogP
2.7
Phase
4

Proparacaine is a topical ophthalmic local anesthetic of the ester class that blocks voltage-gated sodium channels in corneal and conjunctival sensory nerve endings, producing rapid-onset surface analgesia of the eye. It is used exclusively as a topical ophthalmic anesthetic for procedures such as tonometry, foreign body removal, and minor ocular surgery.

Molecular Weight

294.3900 g/mol

LogP

2.70

TPSA

64.80 Ų

Lipinski RO5

Pass

Therapeutic Areas

Age-Related Macular Degeneration Chronic Pain Glaucoma Hypertension Multiple Sclerosis Pain Management

Mechanism of Action

Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mechanism

Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.

2D Structure

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CCCOc1ccc(C(=O)OCCN(CC)CC)cc1N

                

                

                
                

                    
InChI

                    
InChI=1S/C16H26N2O3/c1-4-10-20-15-8-7-13(12-14(15)17)16(19)21-11-9-18(5-2)6-3/h7-8,12H,4-6,9-11,17H2,1-3H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C16H26N2O3

                    

                    
                    

                        
HBD / HBA

                        
1 / 5

                    

                    
                    

                        
Rotatable Bonds

                        
10

                    

                    
                    
                    

                        
Heavy Atoms

                        
21

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Frequently Asked Questions

                

                    
                    

                        
                        

                            
Proparacaine is a topical ophthalmic local anesthetic of the ester class that blocks voltage-gated sodium channels in corneal and conjunctival sensory nerve endings, producing rapid-onset surface analgesia of the eye. It is used exclusively as a topical ophthalmic anesthetic for procedures such as tonometry, foreign body removal, and minor ocular surgery.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Proparacaine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1196.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 4935.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Medical Disclaimer

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.