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Propiolactone

CHEMBL1200627 Phase 4 Approved Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
72.1 g/mol
LogP
-0.2
Phase
4

Beta-propiolactone is a highly reactive alkylating agent that inactivates viruses, bacteria, and other microorganisms by alkylating nucleic acids and proteins, primarily through reaction with nucleophilic sites on nucleobases and amino acids. It has been used for sterilization of vaccines and biological products, though its use is strictly controlled due to significant carcinogenicity and acute toxicity.

Molecular Weight

72.0600 g/mol

LogP

-0.20

TPSA

26.30 Ų

Lipinski RO5

Pass

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
O=C1CCO1

                

                

                
                

                    
InChI

                    
InChI=1S/C3H4O2/c4-3-1-2-5-3/h1-2H2

                

                

                

                    
                    

                        
Molecular Formula

                        
C3H4O2

                    

                    
                    

                        
HBD / HBA

                        
- / 2

                    

                    
                    

                        
Rotatable Bonds

                        
0

                    

                    
                    
                    

                        
Heavy Atoms

                        
5

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Frequently Asked Questions

                

                    
                    

                        
                        

                            
Beta-propiolactone is a highly reactive alkylating agent that inactivates viruses, bacteria, and other microorganisms by alkylating nucleic acids and proteins, primarily through reaction with nucleophilic sites on nucleobases and amino acids. It has been used for sterilization of vaccines and biological products, though its use is strictly controlled due to significant carcinogenicity and acute toxicity.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Propiolactone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1200627.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 2365.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Medical Disclaimer

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.