Propiomazine
Propiomazine is a phenothiazine derivative with sedative, anxiolytic, and antihistamine properties that blocks histamine H1 receptors, dopamine receptors, and muscarinic receptors to produce sedation and reduce anxiety. It is used as a premedication for anesthesia, for the short-term management of insomnia, and for sedation during minor procedures.
Molecular Weight
340.5000 g/mol
LogP
4.80
TPSA
48.90 Ų
Lipinski RO5
Pass
Pharmacokinetics (PK)
Pharmacodynamics (PD)
2D Structure
Cite this structure
Embed this structure
SMILES
CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2
InChI
InChI=1S/C20H24N2OS/c1-5-18(23)15-10-11-20-17(12-15)22(13-14(2)21(3)4)16-8-6-7-9-19(16)24-20/h6-12,14H,5,13H2,1-4H3
Molecular Formula
C20H24N2OS
HBD / HBA
- / 4
Rotatable Bonds
5
Heavy Atoms
24
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
Propiomazine is a phenothiazine derivative with sedative, anxiolytic, and antihistamine properties that blocks histamine H1 receptors, dopamine receptors, and muscarinic receptors to produce sedation and reduce anxiety. It is used as a premedication for anesthesia, for the short-term management of insomnia, and for sedation during minor procedures.
Yes, Propiomazine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201210. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 4940. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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