Propylhexedrine

CHEMBL2105275 Phase 4 Approved Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

155.3 g/mol

LogP

3.5

Phase

4

Propylhexedrine is a sympathomimetic amine and alpha-adrenergic agonist structurally related to methamphetamine that acts as a potent vasoconstrictor of nasal mucosa blood vessels, reducing congestion and improving airflow through the nasal passages. It is available as an over-the-counter nasal decongestant inhaler, though it has abuse potential due to its CNS stimulant properties.

Molecular Weight

155.2800 g/mol

LogP

3.50

TPSA

12.00 Å²

Lipinski RO5

Pass

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

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SMILES

CNC(C)CC1CCCCC1

InChI

InChI=1S/C10H21N/c1-9(11-2)8-10-6-4-3-5-7-10/h9-11H,3-8H2,1-2H3

Molecular Formula

C10H21N

HBD / HBA

1 / 1

Rotatable Bonds

3

Heavy Atoms

11

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Frequently Asked Questions

Propylhexedrine is a sympathomimetic amine and alpha-adrenergic agonist structurally related to methamphetamine that acts as a potent vasoconstrictor of nasal mucosa blood vessels, reducing congestion and improving airflow through the nasal passages. It is available as an over-the-counter nasal decongestant inhaler, though it has abuse potential due to its CNS stimulant properties.

Yes, Propylhexedrine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2105275. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 7558. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Structure

Quick Data

Formula: C10H21N
Synonyms: 1

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Medical Disclaimer

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.