Prothrombin
Prothrombin (Factor II) is a vitamin K-dependent zymogen coagulation factor that is proteolytically activated to thrombin by the prothrombinase complex (Factor Xa + Factor Va), with thrombin subsequently converting fibrinogen to fibrin and activating platelets. Prothrombin complex concentrates containing prothrombin are used for reversal of vitamin K antagonist anticoagulation in urgent situations.
Therapeutic Areas
Mechanism of Action
Serves as an essential micronutrient cofactor in various enzymatic reactions and metabolic processes. Supplementation corrects deficiency states and supports normal physiological function.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Serves as an essential micronutrient cofactor in various enzymatic reactions and metabolic processes. Supplementation corrects deficiency states and supports normal physiological function.
HBD / HBA
- / -
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
Prothrombin (Factor II) is a vitamin K-dependent zymogen coagulation factor that is proteolytically activated to thrombin by the prothrombinase complex (Factor Xa + Factor Va), with thrombin subsequently converting fibrinogen to fibrin and activating platelets. Prothrombin complex concentrates containing prothrombin are used for reversal of vitamin K antagonist anticoagulation in urgent situations.
Serves as an essential micronutrient cofactor in various enzymatic reactions and metabolic processes. Supplementation corrects deficiency states and supports normal physiological function.
Yes, Prothrombin is an approved drug. It has reached clinical phase 4. It is classified as a Protein.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL6068492. Open-access bioactivity database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-02-27.
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