Protirelin
Protirelin (thyrotropin-releasing hormone, TRH) is a synthetic tripeptide hypothalamic hormone that stimulates the pituitary release of thyroid-stimulating hormone (TSH) and prolactin by binding to specific G-protein-coupled TRH receptors on thyrotrophs and lactotrophs. It is used diagnostically as a provocative test for evaluating thyroid function and pituitary TSH reserve, and is under investigation as a treatment for thyroid cancer.
Molecular Weight
362.3800 g/mol
LogP
-2.50
TPSA
150.00 Ų
Lipinski RO5
Pass
Therapeutic Areas
Mechanism of Action
Functions as a diagnostic agent by providing contrast enhancement or radioactive tracer activity that enables visualization of anatomical structures or physiological processes during medical imaging.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Functions as a diagnostic agent by providing contrast enhancement or radioactive tracer activity that enables visualization of anatomical structures or physiological processes during medical imaging.
2D Structure
Cite this structure
Embed this structure
SMILES
NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1
InChI
InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1
Molecular Formula
C16H22N6O4
HBD / HBA
4 / 5
Rotatable Bonds
6
Heavy Atoms
26
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
Protirelin (thyrotropin-releasing hormone, TRH) is a synthetic tripeptide hypothalamic hormone that stimulates the pituitary release of thyroid-stimulating hormone (TSH) and prolactin by binding to specific G-protein-coupled TRH receptors on thyrotrophs and lactotrophs. It is used diagnostically as a provocative test for evaluating thyroid function and pituitary TSH reserve, and is under investigation as a treatment for thyroid cancer.
Functions as a diagnostic agent by providing contrast enhancement or radioactive tracer activity that enables visualization of anatomical structures or physiological processes during medical imaging.
Yes, Protirelin is an approved drug. It has reached clinical phase 4. It is classified as a Protein.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1472. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 638678. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
Embed This Widget
Add the script tag and a data attribute to embed this widget.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<div data-drugfyi="drug" data-slug="protirelin"></div>Embed via iframe for maximum compatibility.
<iframe src="https://drugfyi.com/iframe/drug/protirelin/" width="420" height="400" frameborder="0" style="border:0;border-radius:10px;max-width:100%" loading="lazy"></iframe>Paste this URL in WordPress, Medium, or any oEmbed-compatible platform.
https://drugfyi.com/drug/protirelin/Add a dynamic SVG badge to your README or docs.
[](https://drugfyi.com/drug/protirelin/)Use the native HTML custom element.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<drugfyi-drug slug="protirelin"></drugfyi-drug>