Pseudoephedrine
Pseudoephedrine is a sympathomimetic amine that acts as a direct alpha-adrenergic receptor agonist and indirect sympathomimetic to cause vasoconstriction of nasal mucosal blood vessels, reducing nasal congestion and improving airway patency. It is used as an oral nasal decongestant for the symptomatic relief of nasal congestion associated with the common cold, sinusitis, and allergic rhinitis, and is also a precursor in the illicit synthesis of methamphetamine.
Molecular Weight
165.2300 g/mol
LogP
0.90
TPSA
32.30 Ų
Lipinski RO5
Pass
Therapeutic Areas
Mechanism of Action
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
2D Structure
Cite this structure
Embed this structure
SMILES
CN[C@@H](C)[C@@H](O)c1ccccc1
InChI
InChI=1S/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10+/m0/s1
Molecular Formula
C10H15NO
HBD / HBA
2 / 2
Rotatable Bonds
3
Heavy Atoms
12
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
Pseudoephedrine is a sympathomimetic amine that acts as a direct alpha-adrenergic receptor agonist and indirect sympathomimetic to cause vasoconstriction of nasal mucosal blood vessels, reducing nasal congestion and improving airway patency. It is used as an oral nasal decongestant for the symptomatic relief of nasal congestion associated with the common cold, sinusitis, and allergic rhinitis, and is also a precursor in the illicit synthesis of methamphetamine.
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Yes, Pseudoephedrine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1590. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 7028. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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