💊 Drugs A-Z 🧬 Targets 🛠 Tools 📚 Guides
All Drugs Drug Classes Therapeutic Areas Side Effects
Guides Glossary Timeline
Comparisons Drug Journeys Drug Families
🇺🇸 English 🇰🇷 한국어 🇯🇵 日本語 🇨🇳 中文简体 🇪🇸 Español 🇧🇷 Português 🇮🇳 हिन्दी 🇸🇦 العربية 🇫🇷 Français 🇷🇺 Русский 🇩🇪 Deutsch 🇹🇷 Türkçe 🇻🇳 Tiếng Việt 🇮🇩 Bahasa Indonesia 🇹🇭 ไทย

Ramosetron

CHEMBL1643895 Phase 4 Approved Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
279.3 g/mol
LogP
2.2
Phase
4

Ramosetron is a potent and selective 5-HT3 serotonin receptor antagonist that blocks serotonin-mediated signals in the vagal afferents and central chemoreceptor trigger zone, preventing nausea and vomiting. It is approved in several Asian countries for the prevention of chemotherapy-induced nausea and vomiting and for the treatment of irritable bowel syndrome with diarrhea.

Molecular Weight

279.3400 g/mol

LogP

2.20

TPSA

50.70 Ų

Lipinski RO5

Pass

Therapeutic Areas

Bladder Cancer Breast Cancer Colorectal Cancer Non-Small Cell Lung Cancer Ovarian Cancer Pancreatic Cancer Prostate Cancer Thyroid Cancer

Mechanism of Action

Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mechanism

Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

2D Structure

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
Cn1cc(C(=O)[C@@H]2CCc3[nH]cnc3C2)c2ccccc21

                

                

                
                

                    
InChI

                    
InChI=1S/C17H17N3O/c1-20-9-13(12-4-2-3-5-16(12)20)17(21)11-6-7-14-15(8-11)19-10-18-14/h2-5,9-11H,6-8H2,1H3,(H,18,19)/t11-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C17H17N3O

                    

                    
                    

                        
HBD / HBA

                        
1 / 2

                    

                    
                    

                        
Rotatable Bonds

                        
2

                    

                    
                    
                    

                        
Heavy Atoms

                        
21

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Frequently Asked Questions

                

                    
                    

                        
                        

                            
Ramosetron is a potent and selective 5-HT3 serotonin receptor antagonist that blocks serotonin-mediated signals in the vagal afferents and central chemoreceptor trigger zone, preventing nausea and vomiting. It is approved in several Asian countries for the prevention of chemotherapy-induced nausea and vomiting and for the treatment of irritable bowel syndrome with diarrhea.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Ramosetron is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1643895.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 108000.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Medical Disclaimer

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.