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Ritonavir

CHEMBL163 Phase 4 Approved Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
720.9 g/mol
LogP
6.0
Phase
4

An antiretroviral drug originally used to treat HIV, now most commonly used at low doses as a pharmacokinetic booster to increase the blood levels of other protease inhibitors and antiviral drugs. By inhibiting the CYP3A4 enzyme, it slows the breakdown of companion drugs and allows them to be taken less frequently.

Molecular Weight

720.9000 g/mol

LogP

6.00

TPSA

202.00 Ų

Lipinski RO5

Fail

Therapeutic Areas

Asthma Atrial Fibrillation Bladder Cancer Breast Cancer Cardiovascular Disease Chronic Pain Colorectal Cancer Generalized Anxiety Disorder Heart Failure Hepatitis C HIV/AIDS Hyperlipidemia Hypertension Immunology Infectious Disease Insomnia Leukemia Malaria Non-Alcoholic Fatty Liver Disease Non-Small Cell Lung Cancer Ovarian Cancer Pain Management Pancreatic Cancer Prostate Cancer Thyroid Cancer Tuberculosis Type 2 Diabetes

Mechanism of Action

Inhibits viral protease, an enzyme essential for cleaving polyprotein precursors into functional viral proteins required for viral maturation and infectivity.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mechanism

Inhibits viral protease, an enzyme essential for cleaving polyprotein precursors into functional viral proteins required for viral maturation and infectivity.

2D Structure

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1

                

                

                
                

                    
InChI

                    
InChI=1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C37H48N6O5S2

                    

                    
                    

                        
HBD / HBA

                        
4 / 9

                    

                    
                    

                        
Rotatable Bonds

                        
18

                    

                    
                    
                    

                        
Heavy Atoms

                        
50

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Frequently Asked Questions

                

                    
                    

                        
                        

                            
An antiretroviral drug originally used to treat HIV, now most commonly used at low doses as a pharmacokinetic booster to increase the blood levels of other protease inhibitors and antiviral drugs. By inhibiting the CYP3A4 enzyme, it slows the breakdown of companion drugs and allows them to be taken less frequently.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits viral protease, an enzyme essential for cleaving polyprotein precursors into functional viral proteins required for viral maturation and infectivity.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Ritonavir is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL163.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 392622.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Medical Disclaimer

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.