Safinamide
Taken as an add-on to levodopa therapy, this medication helps smooth out the motor fluctuations that Parkinson's patients experience as their levodopa dose wears off. It works by blocking the breakdown of dopamine and inhibiting certain nerve signals that become overactive in Parkinson's disease.
Molecular Weight
302.3400 g/mol
LogP
2.20
TPSA
64.40 Ų
Lipinski RO5
Pass
Therapeutic Areas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
2D Structure
Cite this structure
Embed this structure
SMILES
C[C@H](NCc1ccc(OCc2cccc(F)c2)cc1)C(N)=O
InChI
InChI=1S/C17H19FN2O2/c1-12(17(19)21)20-10-13-5-7-16(8-6-13)22-11-14-3-2-4-15(18)9-14/h2-9,12,20H,10-11H2,1H3,(H2,19,21)/t12-/m0/s1
Molecular Formula
C17H19FN2O2
HBD / HBA
2 / 4
Rotatable Bonds
7
Heavy Atoms
22
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
Taken as an add-on to levodopa therapy, this medication helps smooth out the motor fluctuations that Parkinson's patients experience as their levodopa dose wears off. It works by blocking the breakdown of dopamine and inhibiting certain nerve signals that become overactive in Parkinson's disease.
Yes, Safinamide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL396778. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 131682. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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