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Selegiline

CHEMBL972 Phase 4 Approved Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
187.3 g/mol
LogP
2.8
Phase
4

Used in the early stages of Parkinson's disease, this medication slows the breakdown of dopamine in the brain by inhibiting the MAO-B enzyme. It may also have mild neuroprotective properties and is sometimes prescribed alongside levodopa to help extend its effectiveness.

Molecular Weight

187.2800 g/mol

LogP

2.80

TPSA

3.20 Ų

Lipinski RO5

Pass

Therapeutic Areas

Alzheimer's Disease Major Depressive Disorder Parkinson's Disease Prostate Cancer Schizophrenia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
C#CCN(C)[C@H](C)Cc1ccccc1

                

                

                
                

                    
InChI

                    
InChI=1S/C13H17N/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13/h1,5-9,12H,10-11H2,2-3H3/t12-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C13H17N

                    

                    
                    

                        
HBD / HBA

                        
- / 1

                    

                    
                    

                        
Rotatable Bonds

                        
4

                    

                    
                    
                    

                        
Heavy Atoms

                        
14

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Frequently Asked Questions

                

                    
                    

                        
                        

                            
Used in the early stages of Parkinson's disease, this medication slows the breakdown of dopamine in the brain by inhibiting the MAO-B enzyme. It may also have mild neuroprotective properties and is sometimes prescribed alongside levodopa to help extend its effectiveness.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Selegiline is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL972.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 26757.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Medical Disclaimer

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.