Stem Bromelain
Stem bromelain is a mixture of proteolytic (cysteine protease) enzymes derived from pineapple (Ananas comosus) stem, used clinically as a debridement agent in the NexoBrid product for enzymatic eschar removal in burns, with investigational applications in bladder and breast cancer. The bromelain proteases selectively digest fibrin and denatured proteins in the burn eschar without destroying viable tissue, enabling non-surgical debridement. Its proteolytic activity may also have anti-inflammatory and anticoagulant properties.
Therapeutic Areas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
HBD / HBA
- / -
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
Stem bromelain is a mixture of proteolytic (cysteine protease) enzymes derived from pineapple (Ananas comosus) stem, used clinically as a debridement agent in the NexoBrid product for enzymatic eschar removal in burns, with investigational applications in bladder and breast cancer. The bromelain proteases selectively digest fibrin and denatured proteins in the burn eschar without destroying viable tissue, enabling non-surgical debridement. Its proteolytic activity may also have anti-inflammatory and anticoagulant properties.
Yes, Stem Bromelain is an approved drug. It has reached clinical phase 4. It is classified as a Enzyme.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4298054. Open-access bioactivity database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-02-27.
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