Sulfameter

CHEMBL1200359 Phase 4 Approved Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

280.3 g/mol

LogP

0.4

Phase

4

Sulfameter is a very long-acting sulfonamide antibiotic with a plasma half-life of approximately 150 hours, used historically once or twice weekly for urinary tract infections and prevention of recurrent rheumatic fever. Its prolonged half-life results from slow renal excretion and extensive plasma protein binding. Like all sulfonamides, it inhibits bacterial dihydropteroate synthase. Its very long half-life increases the risk of cumulative sulfonamide toxicity.

Molecular Weight

280.3100 g/mol

LogP

0.40

TPSA

116.00 Å²

Lipinski RO5

Pass

Therapeutic Areas

Asthma Atrial Fibrillation Benign Prostatic Hyperplasia Colorectal Cancer Gastroesophageal Reflux Disease Generalized Anxiety Disorder Heart Failure Lymphoma Nephrology Ophthalmology Schizophrenia Stroke

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

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SMILES

COc1cnc(NS(=O)(=O)c2ccc(N)cc2)nc1

InChI

InChI=1S/C11H12N4O3S/c1-18-9-6-13-11(14-7-9)15-19(16,17)10-4-2-8(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15)

Molecular Formula

C11H12N4O3S

HBD / HBA

2 / 7

Rotatable Bonds

4

Heavy Atoms

19

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Frequently Asked Questions

Sulfameter is a very long-acting sulfonamide antibiotic with a plasma half-life of approximately 150 hours, used historically once or twice weekly for urinary tract infections and prevention of recurrent rheumatic fever. Its prolonged half-life results from slow renal excretion and extensive plasma protein binding. Like all sulfonamides, it inhibits bacterial dihydropteroate synthase. Its very long half-life increases the risk of cumulative sulfonamide toxicity.

Yes, Sulfameter is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200359. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 5326. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Structure

Quick Data

Formula: C11H12N4O3S

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Medical Disclaimer

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.