Sulfamethazine

CHEMBL446 Phase 4 Approved Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

278.3 g/mol

LogP

0.3

Phase

4

Sulfamethazine (sulfadimidine) is an intermediate-acting sulfonamide antibiotic used in veterinary medicine and historically in human medicine for treatment of urinary tract infections, respiratory infections, and meningitis caused by susceptible bacteria. It inhibits dihydropteroate synthase, blocking folic acid synthesis in susceptible organisms. It is primarily used today in veterinary practice due to sulfonamide resistance and availability of superior human antibiotics.

Molecular Weight

278.3300 g/mol

LogP

0.30

TPSA

106.00 Å²

Lipinski RO5

Pass

Therapeutic Areas

Age-Related Macular Degeneration Alzheimer's Disease Asthma Atrial Fibrillation Bipolar Disorder Bladder Cancer Breast Cancer Cardiovascular Disease Chronic Kidney Disease Chronic Obstructive Pulmonary Disease Chronic Pain Colorectal Cancer Gastroesophageal Reflux Disease Generalized Anxiety Disorder Heart Failure HIV/AIDS Hypertension Infectious Disease Inflammatory Bowel Disease Insomnia Leukemia Lymphoma Major Depressive Disorder Multiple Sclerosis Non-Alcoholic Fatty Liver Disease Non-Small Cell Lung Cancer Obesity Ovarian Cancer Pain Management Pancreatic Cancer Parkinson's Disease Prostate Cancer Psoriasis Respiratory Disease Rheumatoid Arthritis Schizophrenia Stroke Thyroid Cancer Type 2 Diabetes

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

SVG PNG

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SMILES

Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1

InChI

InChI=1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16)

Molecular Formula

C12H14N4O2S

HBD / HBA

2 / 6

Rotatable Bonds

3

Heavy Atoms

19

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Frequently Asked Questions

Sulfamethazine (sulfadimidine) is an intermediate-acting sulfonamide antibiotic used in veterinary medicine and historically in human medicine for treatment of urinary tract infections, respiratory infections, and meningitis caused by susceptible bacteria. It inhibits dihydropteroate synthase, blocking folic acid synthesis in susceptible organisms. It is primarily used today in veterinary practice due to sulfonamide resistance and availability of superior human antibiotics.

Yes, Sulfamethazine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL446. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 5327. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Structure

Quick Data

Formula: C12H14N4O2S
Synonyms: 8

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Medical Disclaimer

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.