Sulfisoxazole
Sulfisoxazole is a short-acting sulfonamide antibiotic with high urinary and tissue concentrations, used for the treatment of urinary tract infections, acute otitis media (in combination with erythromycin), and nocardiosis caused by susceptible organisms. It achieves higher free drug concentrations in urine than many sulfonamides due to lower plasma protein binding, making it particularly effective for urinary infections. Combination with erythromycin was previously used for penicillin-allergic patients with acute otitis media.
Molecular Weight
267.3100 g/mol
LogP
1.00
TPSA
107.00 Ų
Lipinski RO5
Pass
Pharmacokinetics (PK)
Pharmacodynamics (PD)
2D Structure
Cite this structure
Embed this structure
SMILES
Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C
InChI
InChI=1S/C11H13N3O3S/c1-7-8(2)13-17-11(7)14-18(15,16)10-5-3-9(12)4-6-10/h3-6,14H,12H2,1-2H3
Molecular Formula
C11H13N3O3S
HBD / HBA
2 / 6
Rotatable Bonds
3
Heavy Atoms
18
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
Sulfisoxazole is a short-acting sulfonamide antibiotic with high urinary and tissue concentrations, used for the treatment of urinary tract infections, acute otitis media (in combination with erythromycin), and nocardiosis caused by susceptible organisms. It achieves higher free drug concentrations in urine than many sulfonamides due to lower plasma protein binding, making it particularly effective for urinary infections. Combination with erythromycin was previously used for penicillin-allergic patients with acute otitis media.
Yes, Sulfisoxazole is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL453. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5344. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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